April 1, 2008
Genome-wide approaches to studying chromatin modifications.
Publication Date: 2008 Mar PMID: 18250624
Authors: Schones, D. E. - Zhao, K.
Journal: Nat Rev Genet
Over two metres of DNA is packaged into each nucleus in the human body in a manner that still allows for gene regulation. This remarkable feat is accomplished by the wrapping of DNA around histone proteins in repeating units of nucleosomes to form a structure known as chromatin. This chromatin structure is subject to various modifications that have profound influences on gene expression. Recently developed techniques to study chromatin modifications at a genome-wide scale are now allowing researchers to probe the complex components that make up epigenomes. Here we review genome-wide approaches to studying epigenomic structure and the exciting findings that have been obtained using these technologies.
MeSH Categories: Animals, Chromatin/*metabolism, DNA Methylation, *Epigenesis, Genetic, Genome, *Genomics, Histone Code, Humans
post to: CiteULike
Authors: Schones, D. E. - Zhao, K.
Journal: Nat Rev Genet
Over two metres of DNA is packaged into each nucleus in the human body in a manner that still allows for gene regulation. This remarkable feat is accomplished by the wrapping of DNA around histone proteins in repeating units of nucleosomes to form a structure known as chromatin. This chromatin structure is subject to various modifications that have profound influences on gene expression. Recently developed techniques to study chromatin modifications at a genome-wide scale are now allowing researchers to probe the complex components that make up epigenomes. Here we review genome-wide approaches to studying epigenomic structure and the exciting findings that have been obtained using these technologies.
MeSH Categories: Animals, Chromatin/*metabolism, DNA Methylation, *Epigenesis, Genetic, Genome, *Genomics, Histone Code, Humans
post to: CiteULike
Filed under Genetics Publications by Nature Reviews Genetics