March 1, 2008
Research ethics and the challenge of whole-genome sequencing.
Publication Date: 2008 Feb PMID: 18087293
Authors: McGuire, A. L. - Caulfield, T. - Cho, M. K.
Journal: Nat Rev Genet
The recent completion of the first two individual whole-genome sequences is a research milestone. As personal genome research advances, investigators and international research bodies must ensure ethical research conduct. We identify three major ethical considerations that have been implicated in whole-genome research: the return of research results to participants; the obligations, if any, that are owed to participants' relatives; and the future use of samples and data taken for whole-genome sequencing. Although the issues are not new, we discuss their implications for personal genomics and provide recommendations for appropriate management in the context of research involving individual whole-genome sequencing.
MeSH Categories: *Ethics, Research, Family, *Genome, Human, Health Planning Guidelines, Humans, Molecular Sequence Data, Public Policy, Publishing/ethics/legislation & jurisprudence, Research/legislation & jurisprudence, Research Subjects/legislation & jurisprudence, Sequence Analysis, DNA/*ethics, Third-Party Consent/legislation & jurisprudence
post to: CiteULike
Authors: McGuire, A. L. - Caulfield, T. - Cho, M. K.
Journal: Nat Rev Genet
The recent completion of the first two individual whole-genome sequences is a research milestone. As personal genome research advances, investigators and international research bodies must ensure ethical research conduct. We identify three major ethical considerations that have been implicated in whole-genome research: the return of research results to participants; the obligations, if any, that are owed to participants' relatives; and the future use of samples and data taken for whole-genome sequencing. Although the issues are not new, we discuss their implications for personal genomics and provide recommendations for appropriate management in the context of research involving individual whole-genome sequencing.
MeSH Categories: *Ethics, Research, Family, *Genome, Human, Health Planning Guidelines, Humans, Molecular Sequence Data, Public Policy, Publishing/ethics/legislation & jurisprudence, Research/legislation & jurisprudence, Research Subjects/legislation & jurisprudence, Sequence Analysis, DNA/*ethics, Third-Party Consent/legislation & jurisprudence
post to: CiteULike
Filed under Genetics Publications by Nature Reviews Genetics
