May 25, 2010
Publication Date: 2010 Jun PMID: 20479772
Authors: MacLean, R. C. - Hall, A. R. - Perron, G. G. - Buckling, A.
Journal: Nat Rev Genet
Despite efforts from a range of disciplines, our ability to predict and combat the evolution of antibiotic resistance in pathogenic bacteria is limited. This is because resistance evolution involves a complex interplay between the specific drug, bacterial genetics and both natural and treatment ecology. Incorporating details of the molecular mechanisms of drug resistance and ecology into evolutionary models has proved useful in predicting the dynamics of resistance evolution. However, putting these models to practical use will require extensive collaboration between mathematicians, molecular biologists, evolutionary ecologists and clinicians.
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Authors: MacLean, R. C. - Hall, A. R. - Perron, G. G. - Buckling, A.
Journal: Nat Rev Genet
Despite efforts from a range of disciplines, our ability to predict and combat the evolution of antibiotic resistance in pathogenic bacteria is limited. This is because resistance evolution involves a complex interplay between the specific drug, bacterial genetics and both natural and treatment ecology. Incorporating details of the molecular mechanisms of drug resistance and ecology into evolutionary models has proved useful in predicting the dynamics of resistance evolution. However, putting these models to practical use will require extensive collaboration between mathematicians, molecular biologists, evolutionary ecologists and clinicians.
post to: CiteULike
Filed under Genetics Publications by 
May 22, 2010
Publication Date: 2010 Jun PMID: 20479773
Authors: Cirulli, E. T. - Goldstein, D. B.
Journal: Nat Rev Genet
Although genome-wide association (GWA) studies for common variants have thus far succeeded in explaining only a modest fraction of the genetic components of human common diseases, recent advances in next-generation sequencing technologies could rapidly facilitate substantial progress. This outcome is expected if much of the missing genetic control is due to gene variants that are too rare to be picked up by GWA studies and have relatively large effects on risk. Here, we evaluate the evidence for an important role of rare gene variants of major effect in common diseases and outline discovery strategies for their identification.
post to: CiteULike
Authors: Cirulli, E. T. - Goldstein, D. B.
Journal: Nat Rev Genet
Although genome-wide association (GWA) studies for common variants have thus far succeeded in explaining only a modest fraction of the genetic components of human common diseases, recent advances in next-generation sequencing technologies could rapidly facilitate substantial progress. This outcome is expected if much of the missing genetic control is due to gene variants that are too rare to be picked up by GWA studies and have relatively large effects on risk. Here, we evaluate the evidence for an important role of rare gene variants of major effect in common diseases and outline discovery strategies for their identification.
post to: CiteULike
Filed under Genetics Publications by
May 20, 2010
Publication Date: 2010 Jun PMID: 20479774
Authors: Eichler, E. E. - Flint, J. - Gibson, G. - Kong, A. - Leal, S. M. - Moore, J. H. - Nadeau, J. H.
Journal: Nat Rev Genet
Although recent genome-wide studies have provided valuable insights into the genetic basis of human disease, they have explained relatively little of the heritability of most complex traits, and the variants identified through these studies have small effect sizes. This has led to the important and hotly debated issue of where the 'missing heritability' of complex diseases might be found. Here, seven leading geneticists offer their opinion about where this heritability is likely to lie, what this could tell us about the underlying genetic architecture of common diseases and how this could inform research strategies for uncovering genetic risk factors.
post to: CiteULike
Authors: Eichler, E. E. - Flint, J. - Gibson, G. - Kong, A. - Leal, S. M. - Moore, J. H. - Nadeau, J. H.
Journal: Nat Rev Genet
Although recent genome-wide studies have provided valuable insights into the genetic basis of human disease, they have explained relatively little of the heritability of most complex traits, and the variants identified through these studies have small effect sizes. This has led to the important and hotly debated issue of where the 'missing heritability' of complex diseases might be found. Here, seven leading geneticists offer their opinion about where this heritability is likely to lie, what this could tell us about the underlying genetic architecture of common diseases and how this could inform research strategies for uncovering genetic risk factors.
post to: CiteULike
Filed under Genetics Publications by
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